Withering Away
Prepare Esme's medicine in Withering Away: use hot water, not boiling water, and three scoops of herbs. Give it to her before Mass and read the story consequences.
Automatic family thread from Coen's father. PC Gamer's tested route spends 2 morning/noon segments on it, including the second beat after Live Bait and Dead Drop.
Page-Turner can branch off this if you stay with Anca when it rains (+1 segment).